Our research goal is to understand the molecular mechanisms of neuronal　differentiation, brain wiring and functional development of our brain. For this　purpose, we analyze the functions of the genes which are involved in the brain development using mice and zebrafish as model animals. We use the results from these studies to develop the novel therapeutic approaches of neuronal regeneration. We further study the molecular mechanisms of higher brain functions such as learning, memory and emotion. These studies will help us to understand the molecular and cellular mechanisms of neuropsychiatric disorders and contribute to develop the novel therapeutic methods of these human disorders.