Ohshima Lab                                             –{•¶‚ÖƒWƒƒƒ“ƒv
 

Publications


Jounal articles

2022

œWatamura N, Sato K, Shiihashi G, Iwasaki A, Kamano N, Takahashi M, Sekiguchi M, Yamazaki N, Fujioka R, Nagata K, Saito T, Ohshima T, Saido TC, Hiroki Sasaguri H. An isogenic panel of single App knock-in mouse models of Alzheimerfs disease confers differential profiles of ƒÀ-secretase inhibition and endosomal abnormalities. Sci Adv. 8 (23), eabm6155.

œTakahashi M, Nakabayashi T, Naoki Mita, Jin X, Aikawa Y, Sasamoto K, Miyoshi G, Miyata M, Inoue T, Ohshima T. Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons. Mol Brain 15, 37, 2022

œNakanishi Y, Akinaga S, Osawa K, Suzuki N, Sugeno A, Kolattukudy P, Goshima Y, Ohshima T. Regulation of axon pruning of mossy fiber projection in hippocampus by CRMP2 and CRMP4. Dev Neurobiol 82:138-146, 2022

œYamazaki Y, Moizumi M, Nagai J, Hatashita Y, Cai T, Kolattukudy P, Inoue T, Goshima Y, Ohshima T. Requirement of CRMP2 phosphorylation in neuronal migration of developing mouse cerebral cortex and hippocampus and redundant roles of CRMP1 and CRMP4. Cerebral Cortex 32, 520-527.

œAkinaga S, Harada S, Takahashi M, Kaneko A, Kolattukudy P, Goshima Y Ohshima T. Loss of CRMP1 and CRMP2 results in migration defects of Purkinje cells in the X lobule of the mouse cerebellum. Brain Res 1783:147846, 2022

œOsawa K, Nakanishi Y, Noguchi M, Sugeno A, Goshima Y, Ohshima T. CRMP4 is required for the positioning and maturation of newly generated neurons in adult mouse hippocampus. Neurosci Lett. 773: 136503, 2022

œHiroki Sasaguri, Shoko Hashimoto, Naoto Watamura, Kaori Sato, Risa Takamura, Kenichi Nagata, Satoshi Tsubuki, Toshio Ohshima, Atsushi Yoshiki, Shinobu Kitazume, Per Nilsson, Bengt Winblad, Takashi Saito, Nobuhisa Iwata and Takaomi C. Saido. Latest advances in modeling Alzheimerfs disease. Frontiers in Neuroscience 807473, 2022

œTakahashi M, Wei R, Ando K, Ohshima T, Hisanaga SI. The role of the Cdk5 activity in valproic acid-induced anxiety- and depression-like behaviors. Neurochem Res 47:2773-2779

œBrahma MM, Takahashi K, Namekata K, Harada T, Goshima Y and Ohshima T. Genetic inhibition of collapsin response mediator protein-2 phosphorylation ameliorates retinal ganglion cell death in normal-tension glaucoma models. Genes Cells 27, 526-536

œYazawa A, Hensley K, Ohshima T. The Effects of Lanthionine Ketimine 5-ethyl Ester in the ƒ¿-Synucleinopathy model mouse. Neurochem Res 47, 2373?2382.

œKawamoto Y, Tada M, Asano T, Nakamura H, Jitsuki-Takahashi A, Makihara H, Kubota S, Hashiguchi S, Kunii M, Ohshima T, Goshima Y, Takeuchi H, Doi H, Nakamura F, Tanaka F. Phosphorylated CRMP1 is a component of spheroids and involved in early axonal pathology in amyotrophic lateral sclerosis. Front Neurol 2022.994676

œYoujia Guo, Carolina Fiallos Oliveros and Toshio Ohshima. CRMP2 and CRMP4 are required for modulating the formation of commissural tracts in the developing zebrafish forebrain. Dev Neurobiol 82: 533-544.

2021

œShimizu Y, Kiyooka M, Ohshima T. Transcriptome analyses reveal IL6/Stat3 signaling involvement in radial glia proliferation after stab wound injury in the adult zebrafish optic tectum. Frontiers Cell and Developmental Biology 9, 668408 https://doi.org/10.3389/fcell.2021.668408

œTakamura R, Mizuta K, Sekine Y, Islam T, Takashi Saito T, Sato M, Ohkura M, Nakai J, Ohshima T, Saido C. T, Hayashi Y. Modality specific impairment of hippocampal CA1 neurons of Alzheimerfs disease model mice. J Neurosci 41: 5315-5329.

œSugeno A, Ishikawa Y, Ohshima T, Muramatsu R. Simple methods for the lesion detection and severity grading of diabetic retinopathy by image processing and transfer learning. Computers in Biology and Medicine 137, 104795, 2021

œKaori Sato, Naoto Watamura, Ryo Fujioka, Naomi Mihira, Misaki Sekiguchi, Kenichi Nagata, Toshio Ohshima, Takashi Saito, Takaomi C. Saido and Hiroki Sasaguri
A 3rd generation mouse model of Alzheimerfs disease shows early and increased cored plaque pathology composed of wild-type human amyloid ƒÀ peptide. JBC 297, 101004, 2021

2020

œTogashi K, Hasegawa M, Nagai J, Kotaka K, Yazawa A, Takahashi M, Masukawa D, Goshima Y, Hensley K, Ohshima T. Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinsonfs disease via suppressions of CRMP2 phosphorylation and microglial activation. J Neurol Sci 413:116802

œYamazaki Y, Nagai J, Akinaga S, Koga Y, Hasegawa M, Takahashi M, Yamashita N, Kolattukudy P, Goshima Y, Ohshima T. Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: redundant roles of CRMP1 and CRMP4
Brain Res 1736:146762.

œKiyooka M, Shimizu Y, Ohshima T. Histone deacetylase inhibition promotes regenerative neurogenesis after stab wound injury in the adult zebrafish optic tectum. BBRC 529, 366-371

œNakamura F, Ohshima T, Goshima Y. Collapsin response mediator proteins: its biological functions and pathophysiology in neuronal development and regeneration Frontiers Cellular Neuroscience. 14 Article 188

œFujita H, Oikawa R, Hayakawa M, Tomoike F, Kimura Y, Okuno H, Hatashita Y, Fiallos Oliveros C, Bito H, Ohshima T, Tsuneda S, Abe H, and Inoue T. Quantification of native mRNA dynamics in living neurons using fluorescence correlation spectroscopy and reduction-triggered fluorescent probes. JBC 295:7923-7940.

œLi W, Goshima Y, and Ohshima T. Loss of collapsin mediator response protein 4 attenuates 6-hydroxydopamine-induced impairments in a mouse model of Parkinsonfs disease. Neurochem Res 45, 2286-2301.

œSugeno A, Piao W, Yamazaki M, Takahashi K, Arikawa K, Matsunaga H, Hosokawa M, Tominaga D, Goshima Y, Takeyama H, Ohshima T, Cortical transcriptome analysis after spinal cord injury reveals new insights on the regeneration mechanism of CNS upon inhibition of CRMP2 phosphorylation. Neural Regeneration Research 16(7):1258-1265.

2019

œKinoshita Y, Kondo S, Takahashi K, Nagai J, Wakatsuki S, Araki T, Goshima Y, Toshio Ohshima T. Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury. BBRC 514, 1037-1039, 2019

œKondo S, Takahashi K, Kinoshita Y, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T. Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury. Sci Rep 9, 7188, 2019

œNumata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T. Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SOD1G93A. Neurosci Res 139:63-68, 2019

œTogashi, Kentaro; Hasegawa, Masaya; Nagai, Jun; Tonouchi, Aine; Masukawa, Daiki; Hensley, Kenneth; Goshima, Yoshio; Ohshima, Toshio Genetic suppression of CRMP2 phosphorylation improves outcome in MPTP-induced Parkinsonfs model mice. GTC 24, 31-40, 2019

2018

œNakamura H, Takahashi-Jitsuki A, Makihara H, Asano T, Kimura Y, Nakabayashi J, Yamashita N, Nakamura F, Ohshima T, Hirano H, Tanaka F, Goshima Y. Proteome and behavioral alternations in knock-in mice expressing nonphosphorylated CRMP2S522A. Neurochem Int. 119:207-217, 2018

œUeda Y, Shimizu Y, Ishitani T, Ohshima T. Involvement of Shh and Notch signalings in regenerative neurogenesis in adult zebrafish optic tectum after stab injury. J Comp Neurol 526, 2360-2372.

œKuroki S, Yoshida T, Tsutsui H, Iwama M, Ando R, Michikawa T, Miyawaki A, Ohshima T.
Itohara S. Excitatory Neuronal Hubs Configure Multisensory Integration of Slow Waves in Association Cortex.
Cell Rep. 22:2873-2885, 2018

œHashimoto S Ishii A, Kamano N, Watamura N, Saito T, Ohshima T, Yokosuka M, Saido T. C., Endoplasmic reticulum stress responses in mouse models of Alzheimerfs disease: Overexpression paradigm versus knock-in paradigm. JBC 293, 3118-3125, 2018

œChiang M-C, Huang A.J.Y., Wintzer M.E., Ohshima T and McHugh T. J. A role for CA3 in social recognition memory. Behavioral Brain Res 354, 22-30, 2018

œShimizu Y, Ueda Y, Ohshima T. Wnt signaling regulates proliferation and differentiation of radial glia in regenerative processes after stab injury in the optic tectum of adult zebrafish. Glia 66:1382-1394, 2018.

œKamiki E, Boehringer R, Polygalov D, Ohshima T, McHugh T. Inducible knockout of the Cyclin-dependent kinase 5 activator p35 alters hippocampal spatial coding and neuronal excitability. Frontiers in Cellular Neuroscience Volume 12 Article 138, 2018


2017

œXu B, Kumazawa A, Kobayashi S, Hisanaga S-I, Inoue T, Ohshima T.
Cdk5 activity is required for Purkinje cell dendritic growth in cell-autonomous and non-cell-autonomous manners
Dev Neurobiol 77, 1175-1187, 2017

œShitasako S, Ito Y, Ito R, Ueda Y, Shimizu Y, Ohshima T.
Wnt and Shh signals regulate neural stem cell proliferation and differentiation in the optic tectum of adult zebrafish.
Dev Neurobiol 77, 1206-1220, 2017

œNozawa K, Lin Y, Kubodera R, Shimizu Y, Tanaka T, Ohshima T.
Zebrafish Mecp2 is required for proper axonal elongation of motor neurons and synapse formation.
Dev Neurobiol 77, 1101-1113, 2017

œNagai J, Baba R, Ohshima T.
CRMPs function in neurons and glial cells: potential therapeutic targets for neurodegenerative diseases and CNS injury.
Mol Neurobiol 2017 54:4243-4256 doi:10.1007/s12035-016-0005-1


œNakamura F, Okada T,Shishikura M, Uetani N , Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y and Stephen M. Strittmatter
Protein Tyrosine Phosphatase ƒÂ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase
Journal of Neuroscience 21 June 2017 2519-16 doi:10.1523/JNEUROSCI.2519-16.2017


œTobe et al.
Probing the lithium response pathway in hiPSCs implicates the phosphoregulatory setpoint for a cytoskeletal modulator in bipolar pathogenesis.
PNAS 2017 May 30;114(22):E4462-E4471 doi: 10.1073/pnas.1700111114.

œSasamoto K, Nagai J, Nakabayashi T, He X, Ohshima T.
Cdk5 is required for the positioning and survival of GABAergic neurons in developing mouse striatum.
Dev Neurobiol Apr;77(4):483-492. 2017 doi: 10.1002/dneu.22424.

œSato Y, Yano H, Tanaka H, Ohshima T.
Optic nerve input-dependent regulation of neural stem cell proliferation in the optic tectum of adult zebrafish.
Dev Neurobiol 2017 Apr;77(4):474-482. doi: 10.1002/dneu.22423.

œTakamura R, Watamura N, Nikkuni M, Ohshima T.
All-trans retinoic acid improved impaired proliferation of neural stem cells and suppressed microglial activation in the hippocampus of Alzheimer mouse model.
J Neurosci Res 95, 897-906, 2017

œKotaka K, Nagai J, Hensley K, Ohshima T.
Lanthionine ketimine ester promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth.
BBRC 483:759-764, 2017

œTakaya R, Nagai J, Piao W. Niisato E, Nakabayashi T, Yamazaki Y, Nakamura F, Yamashita N, Kolattukudy P. Goshima Y, Ohshima T.
CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.
Brain Res 1655:161-167, 2017

2016

œToba J, Nikkuni M, Ishizeki M, Yoshii A, Watamura N, Inoue T, Ohshima T.
PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Αβ deposition stage in APPswe/PS1dE9 Alzheimerfs disease model mice.
BBRC 473:1039-44, 2016

œTonouchi A, Nagai J, Togashi K, Goshima Y, Ohshima T.
Loss of CRMP4 suppresses dopaminergic neuron death in an MPTP-induced mouse model of Parkinsonfs disease.
J Neurochem 137:795-805

œNagai J, Takaya R, Piao W, Goshima Y, Ohshima T
Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury.
Mol Cell Neurosci. 74:42-48.

œMita N., He X., Mishiba T., Ohshima T.
Cyclin-dependent kinase 5 regulates dendritic spine formation and maintenance of cortical neuron in the mouse brain.
Cerebral Cortex 26:967-76, 2016

œNagai J, Owada K, Kitamura Y, Goshima Y, Ohshima T.
Inhibition of CRMP2 phosphorylation repairs injured CNS by reducing inhibitory response and enhancing sensitivity to neurotrophic factor.
Exp Neurol. 277, 283-295

œJin X, Sasamoto K, Nagai J, Yamazaki Y, Saito K, Goshima Y, Inoue T, Ohshima T. Phosphorylation of CRMP2 by Cdk5 regulates dendritic spine development of cortical neuron in the mouse hippocampus.
Neural plasticity Article ID 6790743

œWatamura N, Toba, J, Yoshii A, Ohshima T.
Co-localization of phosphorylated forms of WAVE1, CRMP2 and Tau in Alzheimerfs disease model mice: Involvement of Cdk5 phosphorylation and the effect of ATRA treatment.
J Neurosci Res 94, 15-26
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2015

œShimizu Y, Ito Y, Tanaka H, Ohshima T. 2015.
Radial glial cell-specific ablation in adult zebrafish brain.
Genesis 53, 431-9

œMishiba T, Tanaka M, Mita N, He X, Sasamoto K, Itohara S, Ohshima T. 2015.
Cdk5/p35 functions as a crucial regulator of spatial learning and memory.
Mol Brain 7, 82

œOhshima T.
Review: Neuronal migration and protein kinases.
Frontiers in Neuroscience 8, 458


œNagai J, Kitamura Y, Owada K, Yamashita N, Takei K, Yoshio Goshima Y, Ohshima T.
Genetic deletion of Crmp4 promotes axonal regrowth after spinal cord injury by reducing microtubule destabilization and inflammatory responses.
Sci. Rep 5, 8269

2014
œDozawa M, Kono H, Ito Y, Tanaka H, Ohshima T.
Valproic acid, a histone deacetylase inhibitor, regulates cell proliferation in the adult zebrafish optic tectum.
Dev Dyn 243, 1401-1415.

œUtreras E, Hamada R, Prochazkova M, Terse A, Takahashi S, Ohshima T, Kulkarni AB.
Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARƒÁ agonist improves neuronal loss and early lethality.
J Neuroinflammation. 2014; 11: 28. Published online Feb 5, 2014. doi: 10.1186/1742-2094-11-28

œKuwabara Y, Ishizeki M, Watamura N, Toba J, Yoshii A, Inoue T, Ohshima T. Impairments of long-term depression (LTD) induction and motor coordination precede AƒÀ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice.

Kuwabara Y, Ishizeki M, Watamura N, Toba J, Yoshii A, Inoue T, Ohshima T.
J. Neurochem. (2014) 10.1111/jnc.12728

œTakahashi M, Ishida M, Saito T, Ohshima T, Hisanaga S.
Valproic acid downregulates Cdk5 activity via the transcription of the p35 mRNA.

Biochem Biophys Res Commun. 2014 May 16;447(4):678-82. doi: 10.1016/j.bbrc.

œKobayashi T,Saito T,Sato K,Furusawa K,Hosokawa T,Tsutsumi K,Asada A,Kamada S,Ohshima T and Hisanaga S.
Phosphorylation of Cdk5 at Tyr15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5.
J Biol Chem. 2014 May 28. pii: jbc.M113.501148.

œHe X, Ishizeki M, Mita N, Wada S, Araki Y, Ogura H, Abe M, Yamazaki M, Sakimura K, Mikoshiba K, Inoue T, Ohshima T.
Cdk5/p35 is required for motor coordination and cerebellar plasticity.
J Neurochem. 2014 May 7. doi: 10.1111/jnc.12756.


2013
œRii Morimura, Keisuke Nozawa, Hideomi Tanaka, Toshio Ohshima. Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) Is Required For Positioning of Caudal Primary Motor Neurons in the Zebra?sh Spinal Cord.
Dev. Neurobiol.


œKumazawa A, Mita N, Hirasawa M, Adachi T, Suzuki H, Shafeghat N, Kulkarni AB, Mikoshiba K, Inoue T, Ohshima T.Cyclin-dependent kinase 5 is required for normal cerebellar development.
Mol. Cell Neurosci.


œHuilgol D, Udin S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner R, Meyer G, Ohshima T. Pleasure SJ, Zhao Y, Tole S. Dual origin of the mammalian accessory olfactory bulb revealed by an an evolutionarily conserved long distance migratory stream.
Nat. Neurosci. 16, 157-165.

œMirco Brondolin, Susanne Berger, Michael Reinke, Hideomi Tanaka, Toshio Ohshima, Bernhard Fus and Michael Hoch Identification and expression analysis of the Ceramide synthase gene family in zebrafish Danio rerio.
Dev Dyn. 242, 189-200, 2013


œBrondolin M, Berger S, Reinke M, Tanaka H, Ohshima T, FuƒÀ B, Hoch M.
Identification and expression analysis of the zebrafish homologs of the ceramide synthase gene family.
Dev Dyn. 2013 Feb;242(2):189-200. doi: 10.1002/dvdy.23913.

œIsono T, Yamashita N, Obara M, Araki T, Nakamura F, Kamiya Y, Alkam T, Nitta A, Nabeshima T, Mikoshiba K, Ohshima T, Goshima Y.
Amyloid-ƒÀ????? induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2.
Neurosci Res. 2013 Nov;77(3):180-5. doi: 10.1016/j.neures.2013.08.005.

œKwak Y, Jeong J, Lee S, Park YU, Lee SA, Han DH, Kim JH, Ohshima T, Mikoshiba K, Suh YH, Cho S, Park SK.
Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.
J Biol Chem. 2013 Dec 27;288(52):36878-89. doi: 10.1074/jbc.M113.494856.


œChihiro Hisatsune, Hiroyuki Miyamoto, Moritoshi Hirono, Naohide Yamaguchi, Takeyuki Sugawara, Naoko Ogawa, Etsuko Ebisui, Toshio Ohshima, Masahisa Yamada, Takao K. Hensch, Mitsuharu Hattori and Katsuhiko Mikoshiba.
IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice.
Front. Neural Circuits, 04 October 2013 | doi: 10.3389/fncir.2013.00156


2012
œYamashita N, Ohshima T, Nakamura F, Kolattukudy P, Honnorat J, Mikoshiba K, Goshima Y. (2012) Phosphorylation of CRMP2 is involved in proper dendritic field organization.
J. Neurosci. 32, 1360-1365, 2012.

œTerabayashi T, Sakaguchi M, Shinmyozu K, Ohshima T, Johjima A, et al. (2012) Phosphorylation of Kif26b Promotes Its Polyubiquitination and Subsequent Proteasomal Degradation during Kidney Development.
PLoS ONE 7(6): e39714.


œTanaka H, Morimura R, Ohshima T. Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish.
Dev Biol.


œNiisato E, Nagai J, Yamashita N, Abe T, Kiyonari H, Goshima Y, Ohshima T. CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neuorns in the mouse hippocampus. Dev. Neurobiol.

œNiisato E, Nagai J, Yamashita N, Nakamura F, Goshima Y and Ohshima T. Phosphorylation of CRMP2 is involved in proper bifurcation of the apical dendrite of hippocampal CA1 pyramidal neurons.
Dev Neurobiol.


œNagai J, Goshima Y, Ohshima T. CRMP4 mediates MAG-induced inhibition of axonal outgrowth and protection against Vincristine-induced axonal degeneration.
Neurosci Lett. 2012.19, 56-61.

2011
œTanaka H, Nojima Y, Shoji W, Sato M, Nakayama R, Ohshima T, Okamoto H.(2011) Islet1 selectively promotes peripheral axon outgrowth in Rohon-Beard primary sensory neurons. Dev.
Dyn. 240, 9-22

œOhata S, Aoki R, Kinoshita S, Yamaguchi M, Tsuruoka-Kinoshita S, Tanaka H, Wada H, Watabe S, Tsuboi T, Masai I, Okamoto H. (2011) Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells.
Neuron. 69, 215-230.


œHe X, Takahashi S, Suzuki H, Hashikawa, T, Kulkarni AB, Mikoshiba K, Ohshima T. Hypomyelination Phenotype Caused by Impaired Differentiation of Oligodendrocytes in Emx1-cre Mediated Cdk5 Conditional Knockout Mice.
Neurochem Res.36, 1293-1303, 2011.
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2010
œTsutsumi K, Takano T, Endo R, Fukuda M, Ohshima T,Tomomura M, Hisanaga S. (2010) Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.
PLoS ONE 5(4): e10260. doi:10.1371/journal.pone.0010260


œJin J, Suzuki H, Hirai S, Mikoshiba K, Ohshima T. (2010) JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration.
Dev. Neurobiol. 70:929-942.


œIto Y, Tanaka H, Okamoto H, Ohshima T. (2010) Characterization of neural stem cells and their progeny in the adult zebrafish optic tectum.
Dev. Biol.@342, 26-38.


œ Amo R, Aizawa H, Takahoko M, Kobayashi M, Takahashi R, Aoki T, Okamoto H. (2010) Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula.
J. Neurosci. 30(4), 1566-1574.

2009
œTakahashi S, Ohshima T, Hirasawa M, Pareek TK, Bugge TH, Morozov A, Fujieda K, Brady RO, Kulkarni AB. (2009) Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.
American J. Pathology. 176,320-329.

œUchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, Goshima Y. (2009) Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.
J. Biol. Chem. 284, 27393-401.

œEndo R, Saito T, Asada A, Kawahara H, Ohshima T, Hisanaga S. (2009) Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 Cyclin-dependent kinase 5 activator.
J. Biol. Chem. 284, 26029-39.

œNakamura F, Ugajin K, Yamashita N, Okada T, Uchida Y, Taniguchi M, Ohshima T, Goshima Y.
Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.
J. Comp. Neurol. 516, 360-375.


œOhata S, Kinoshita S, Aoki R, Tanaka H, Wada H, Tsuruoka-Kinoshita S, Tsuboi T, Watabe S, Okamoto H,
Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain,
Development 136, 1653-1663.

2008
œKaminosono S, Saito T, Oyama F, Ohshima T, Asada A, Nagai Y, Nukina N, Hisanaga S.
Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability.
J. Neurosci. 28, 8747-55.


œNishiwaki Y, Komori A, Sagara H, Suzuki E, Manabe T, Hosoya T, Nojima Y, Wada H, Tanaka H, Okamoto H, Masai I,
Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive degeneration of cone photoreceptors in zebrafish,
Mech. Dev. 125, 932-946.

2007
œHirota Y, Ohshima T, Kaneko N, Ikeda M, Iwasato T, Kulkarni AB, Mikoshiba K, Okano H, Sawamoto K.
Cyclin-dependent kinase 5 is required for control of neuroblast migration in the postnatal subventricular zone.
J. Neurosci. 27, 12829-38.

œYamashita N, Morita A, Uchida Y, Nakamura F, Usui H, Ohshima T, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y.
Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1.
J. Neurosci. 27, 12546-54.

œ Remedios R, Huilgol D, Saha B, Hari P, Bhatnagar L, Kowalczyk T, Hevner RF, Suda Y, Aizawa S, Ohshima T, Stoykova A, Tole S.
A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex.
Nat. Neurosci. 10, 1141-50.

œOhshima T, Hirasawa M, Tabata H, Mutoh T, Adachi T, Suzuki H, Saruta K, Iwasato T, Itohara S, Hashimoto M, Nakajima K, Ogawa M, Kulkarni AB, Mikoshiba K.
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex.
Development 134, 2273-2282.

œOhshima T, Suzuki H, Morimura T, Ogawa M, Mikoshiba K.
Modulation of Reelin signaling by Cyclin-dependent kinase 5. Brain Res. 1140, 84-95.

œHayashi K, Ohshima T, Hashimoto M, Mikoshiba K.
Pak1 regulates dendritic branching and spine formation.
Dev. Neurobiol.@67, 655-669.


œTanaka H, Maeda R, Shoji W, Wada H, Masai I, Shiraki T, Kobayashi M, Nakayama R, Okamoto H,
Novel mutations affecting axon guidance in zebrafish and a role for plexin signaling in the guidance of trigeminal and facial nerve axons.
Development 134, 3259-3269.

2006
œYamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T. Goshima Y.
CRMP1 mediates Reelin signaling in cortical neuronal migration.
J. Neurosci. 26, 13357-62.

œHayashi K, Pan Y, Shu H, Ohshima T , Kansy W J, White C L III, Tamminga C A, Sobel A, Curmi P A, Mikoshiba K, Bibb J A.
Phosphorylation of the tubulin binding protein, stathmin by Cdk5 and MAP kinase in the brain. J. Neurochem.@99, 237-250.


œ Wada H, Tanaka H, Nakayama S, Iwasaki M, Okamoto H,
Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain.
Development 133, 4749-4759.

2005
œLi C, Sasaki Y, Takei K, Yamamoto H, Shouji M, Sugiyama Y, Kawakami T, Nakamura F, Yagi T, Ohshima T, Goshima Y.
Correlation between Semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E.
J. Neurosci. 24, 6161-6170.

œWei F, Nagashima K, Ohshima T. Saheki Y, Matsushita M, Yamada Y, Mikoshiba K, Seino Y, Matsui H, Tomizawa K.
Cdk5-dependent regulation of glucose-stimulated insulin secretion.
Nat. Med. 11, 1104-1108.

œOhshima T, Ogura H, Tomizawa K, Hayashi K, Suzuki H, Saito T, Kamei H, Nishi A, Bibb J A, Hisanaga S, Matsui H, Mikoshiba K.
Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice.
J. Neurochem. 94, 917-25.

œWei F, Tomizawa K, Ohshima T, Asada A, Saito T, Nguyen C, Bibb J A, Ishiguro K, Kulkarni A B, Pant H C, Mikoshiba K, Hisanaga S.
Control of Cdk5 activity by glutamatergic regulation of p35 stability.
J. Neurochem.@93, 502-512.

œTakahashi S, Ohshima T, Cho A, Sreenth T, Iadaroa M J, Pant H C, Kim Y, Narin A C, Brady R O, Greegard P, Kulkarni A B.
Increased activity of cyclin-dependent kinase 5 leads to attenuating of cocaine-mediated dopamine signaling.
Proc. Natl. Acad. Sci. USA 102, 1737-1742.

œUchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y.
Semaphorin-3A signaling is mediated via sequential Cdk5-GSK3b phosphorylation of CRMP2Fimplication of common phosphorylating mechanism underlying axon guidance and Alzheimerfs disease.
Genes to Cells 10, 165-179.


œWada H, Iwasaki M, Sato T, Masai I, Nishiwaki Y, Tanaka H, Sato A, Nojima Y,Okamoto H, Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryos.
Development 132, 2273-2285.

œKawakami A, Nojima Y, Toyoda A, Takahoko M, Satoh M, Tanaka H, Wada H, Masai I, Terasaki H, Sakaki Y, Takeda H, Okamoto H,
The zebrafish-secreted matrix protein you/scube2 is implicated in long-range@regulation of hedgehog signaling.
Curr. Biol. 8, 480-488