武岡 真司 Shinji Takeoka
所 属
早稲田大学 先進理工学部 生命医科学科 教授
研究分野
Biomedical Engineering, Biomaterials, Polymer Science, Blood Substitute, and Nanomedicine
研究内容
Molecular assembling and cooperative phenomena of biomolecules including biomacromolecules give us useful implications to construct smart nanodevices having multi-functions. We quests the molecular assembling science and engineering of amphiphilic molecules such as phospholipids, glycolipids, aminolipids, and polyethyleneglycol (PEG)-lipids interacted with biomacromoleucles such as bioactive compounds, genes or proteins, in order to design and construct novel nanocarriers for controlled drug delivery and release systems. We also proposed novel polymer thin films (nanosheets) made of biocompatible and biodegradable materials for biomedical applications such as wound dressing materials or drug releasing materials. Recent challenges include the fabrication of inkjet-printed conductive and elastic nanosheet for printable and flexible electronics and stimuli-sensitive fluorescent nanosheets as microenvironment (pH and temperature) sensing platforms.
最近の研究成果
1. Tianshu Li, Jieyan He, Gabor Horvath, Tomasz Prochnicki, Eicke Latz, Shinji Takeoka
Lysine-containing cationic liposomes activate the NLRP3 inflammasome: effect of a spacer between the head group and the hydrophobic moieties of the lipids.
Nanomedine: nanotechnology, biology and medicine, Volume14, 279-288(2018).
2. Agostina Grillone, Tianshu Li, Matteo Battaglini, Alice Scarpellini, Mirko Prato, Shinji Takeoka and Gianni Ciofani
Preparation, Characterization, and Preliminary In Vitro Testing of Nanoceria-Loaded Liposomes
Nanomaterials, 7(9), 276(2017).
3. Yuma Tetsu, Kento Yamagishi, Akira Kato, Yuya Matsumoto, Mariko Tsukune, Yo Kobayashi, Masakatsu G. Fujie, Shinji Takeoka
and Toshinori Fujie
Ultrathin epidermal strain sensor based on an elastomer nanosheet with an inkjet-printed conductive polymer
Applied Physics Express (APEX), 10, 087201(2017).
4. Kohei Kubota, Kohei Onishi, Kazuaki Sawaki, Tianshu Li, Kaoru Mitsuoka, Takaaki Sato, Shinji Takeoka
Effect of the nanoformulation of siRNA-lipid assemblies on their cellular uptake and immune stimulation
International Journal of Nanomedicine , 12, 5121-5133 (2017).
5. Silvia Taccola, Virginia Pensabene, Toshinori Fujie, Shinji Takeoka, Nicola M. Pugno, Virgilio Mattoli
On the injectability of free-standing magnetic nanofilms
Biomedical Microdevices, 19: 51(2017).