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Publications
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●Takamura R, Watamura N, Nikkuni M, Ohshima T.
All-trans retinoic acid improved impaired proliferation of neural stem cells and suppressed microglial activation in the hippocampus of Alzheimer mouse model.
J Neurosci Res 95, 897-906, 2017
●Kotaka K, Nagai J, Hensley K, Ohshima T.
Lanthionine ketimine ester promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth.
BBRC 483:759-764, 2017
●Takaya R, Nagai J, Piao W. Niisato E, Nakabayashi T, Yamazaki Y, Nakamura F, Yamashita N, Kolattukudy P. Goshima Y, Ohshima T.
CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain.
Brain Res 1655:161-167, 2017
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●Toba J, Nikkuni M, Ishizeki M, Yoshii A, Watamura N, Inoue T, Ohshima T.
PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Αβ
deposition stage in APPswe/PS1dE9 Alzheimer’s disease model mice.
BBRC 473:1039-44, 2016
●Tonouchi A, Nagai J, Togashi K, Goshima Y, Ohshima T.
Loss of CRMP4 suppresses dopaminergic neuron death in an MPTP-induced mouse model of Parkinson’s disease.
J Neurochem 137:795-805
●Nagai J, Takaya R, Piao W, Goshima Y, Ohshima T
Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and
induces nociceptive recovery after spinal cord injury.
Mol Cell Neurosci. 74:42-48.
●Mita N., He X., Mishiba T., Ohshima T.
Cyclin-dependent kinase 5 regulates dendritic spine formation and maintenance
of cortical neuron in the mouse brain.
Cerebral Cortex 26:967-76, 2016
●Nagai J, Owada K, Kitamura Y, Goshima Y, Ohshima T.
Inhibition of CRMP2 phosphorylation repairs injured CNS by reducing inhibitory response and enhancing sensitivity to neurotrophic factor.
Exp Neurol. 277, 283-295
●Jin X, Sasamoto K, Nagai J, Yamazaki Y, Saito K, Goshima Y, Inoue T, Ohshima
T. Phosphorylation of CRMP2 by Cdk5 regulates dendritic spine development
of cortical neuron in the mouse hippocampus.
Neural plasticity Article ID 6790743
●Watamura N, Toba, J, Yoshii A, Ohshima T.
Co-localization of phosphorylated forms of WAVE1, CRMP2 and Tau in Alzheimer’s
disease model mice: Involvement of Cdk5 phosphorylation and the effect
of ATRA treatment.
J Neurosci Res 94, 15-26 |
●Shimizu Y, Ito Y, Tanaka H, Ohshima T. 2015.
Radial glial cell-specific ablation in adult zebrafish brain.
Genesis 53, 431-9
●Mishiba T, Tanaka M, Mita N, He X, Sasamoto K, Itohara S, Ohshima T. 2015.
Cdk5/p35 functions as a crucial regulator of spatial learning and memory.
Mol Brain 7, 82
●Ohshima T.
Review: Neuronal migration and protein kinases.
Frontiers in Neuroscience 8, 458
●Nagai J, Kitamura Y, Owada K, Yamashita N, Takei K, Yoshio Goshima Y,
Ohshima T.
Genetic deletion of Crmp4 promotes axonal regrowth after spinal cord injury by reducing microtubule destabilization and inflammatory responses.
Sci. Rep 5, 8269 |
●Utreras E, Hamada R, Prochazkova M, Terse A, Takahashi S, Ohshima T, Kulkarni AB.
Suppression of neuroinflammation in forebrain-specific Cdk5 conditional
knockout mice by PPARγ agonist improves neuronal loss and early lethality.
J Neuroinflammation. 2014; 11: 28. Published online Feb 5, 2014. doi: 10.1186/1742-2094-11-28
●Kuwabara Y, Ishizeki M, Watamura N, Toba J, Yoshii A, Inoue T, Ohshima
T. Impairments of long-term depression (LTD) induction and motor coordination
precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic
mice.
Kuwabara Y, Ishizeki M, Watamura N, Toba J, Yoshii A, Inoue T, Ohshima T.
J. Neurochem. (2014) 10.1111/jnc.12728
●Takahashi M, Ishida M, Saito T, Ohshima T, Hisanaga S.
Valproic acid downregulates Cdk5 activity via the transcription of the p35 mRNA.
Biochem Biophys Res Commun. 2014 May 16;447(4):678-82. doi: 10.1016/j.bbrc.
●Kobayashi T,Saito T,Sato K,Furusawa K,Hosokawa T,Tsutsumi K,Asada A,Kamada
S,Ohshima T and Hisanaga S.
Phosphorylation of Cdk5 at Tyr15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5.
J Biol Chem. 2014 May 28. pii: jbc.M113.501148.
●He X, Ishizeki M, Mita N, Wada S, Araki Y, Ogura H, Abe M, Yamazaki M,
Sakimura K, Mikoshiba K, Inoue T, Ohshima T.
Cdk5/p35 is required for motor coordination and cerebellar plasticity.
J Neurochem. 2014 May 7. doi: 10.1111/jnc.12756.
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●Rii Morimura, Keisuke Nozawa, Hideomi Tanaka, Toshio Ohshima. Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) Is Required For Positioning of Caudal Primary Motor Neurons in the Zebra?sh Spinal Cord.
Dev. Neurobiol.
●Kumazawa A, Mita N, Hirasawa M, Adachi T, Suzuki H, Shafeghat N, Kulkarni
AB, Mikoshiba K, Inoue T, Ohshima T.Cyclin-dependent kinase 5 is required
for normal cerebellar development.
Mol. Cell Neurosci.
●Huilgol D, Udin S, Shimogori T, Saha B, Roy A, Aizawa S, Hevner R, Meyer
G, Ohshima T. Pleasure SJ, Zhao Y, Tole S. Dual origin of the mammalian
accessory olfactory bulb revealed by an an evolutionarily conserved long
distance migratory stream.
Nat. Neurosci. 16, 157-165.
●Mirco Brondolin, Susanne Berger, Michael Reinke, Hideomi Tanaka, Toshio Ohshima, Bernhard Fus and Michael Hoch Identification and expression analysis of the Ceramide synthase gene family in zebrafish Danio rerio.
Dev Dyn. 242, 189-200, 2013
●Brondolin M, Berger S, Reinke M, Tanaka H, Ohshima T, Fuβ B, Hoch M.
Identification and expression analysis of the zebrafish homologs of the
ceramide synthase gene family.
Dev Dyn. 2013 Feb;242(2):189-200. doi: 10.1002/dvdy.23913.
●Isono T, Yamashita N, Obara M, Araki T, Nakamura F, Kamiya Y, Alkam T,
Nitta A, Nabeshima T, Mikoshiba K, Ohshima T, Goshima Y.
Amyloid-β????? induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2.
Neurosci Res. 2013 Nov;77(3):180-5. doi: 10.1016/j.neures.2013.08.005.
●Kwak Y, Jeong J, Lee S, Park YU, Lee SA, Han DH, Kim JH, Ohshima T, Mikoshiba
K, Suh YH, Cho S, Park SK.
Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein
by direct phosphorylation.
J Biol Chem. 2013 Dec 27;288(52):36878-89. doi: 10.1074/jbc.M113.494856.
●Chihiro Hisatsune, Hiroyuki Miyamoto, Moritoshi Hirono, Naohide Yamaguchi,
Takeyuki Sugawara, Naoko Ogawa, Etsuko Ebisui, Toshio Ohshima, Masahisa
Yamada, Takao K. Hensch, Mitsuharu Hattori and Katsuhiko Mikoshiba.
IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent
dystonia by triggering tonic Purkinje cell firings in mice.
Front. Neural Circuits, 04 October 2013 | doi: 10.3389/fncir.2013.00156
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●Yamashita N, Ohshima T, Nakamura F, Kolattukudy P, Honnorat J, Mikoshiba
K, Goshima Y. (2012) Phosphorylation of CRMP2 is involved in proper dendritic
field organization.
J. Neurosci. 32, 1360-1365, 2012.
●Terabayashi T, Sakaguchi M, Shinmyozu K, Ohshima T, Johjima A, et al.
(2012) Phosphorylation of Kif26b Promotes Its Polyubiquitination and Subsequent
Proteasomal Degradation during Kidney Development.
PLoS ONE 7(6): e39714.
●Tanaka H, Morimura R, Ohshima T. Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish.
Dev Biol.
●Niisato E, Nagai J, Yamashita N, Abe T, Kiyonari H, Goshima Y, Ohshima
T. CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neuorns
in the mouse hippocampus. Dev. Neurobiol.
●Niisato E, Nagai J, Yamashita N, Nakamura F, Goshima Y and Ohshima T.
Phosphorylation of CRMP2 is involved in proper bifurcation of the apical
dendrite of hippocampal CA1 pyramidal neurons.
Dev Neurobiol.
●Nagai J, Goshima Y, Ohshima T. CRMP4 mediates MAG-induced inhibition of
axonal outgrowth and protection against Vincristine-induced axonal degeneration.
Neurosci Lett. 2012.19, 56-61. |
●Tanaka H, Nojima Y, Shoji W, Sato M, Nakayama R, Ohshima T, Okamoto H.(2011) Islet1 selectively promotes peripheral axon outgrowth in Rohon-Beard primary sensory neurons. Dev.
Dyn. 240, 9-22
●Ohata S, Aoki R, Kinoshita S, Yamaguchi M, Tsuruoka-Kinoshita S, Tanaka
H, Wada H, Watabe S, Tsuboi T, Masai I, Okamoto H. (2011) Dual roles of
Notch in regulation of apically restricted mitosis and apicobasal polarity
of neuroepithelial cells.
Neuron. 69, 215-230.
●He X, Takahashi S, Suzuki H, Hashikawa, T, Kulkarni AB, Mikoshiba K, Ohshima
T. Hypomyelination Phenotype Caused by Impaired Differentiation of Oligodendrocytes
in Emx1-cre Mediated Cdk5 Conditional Knockout Mice.
Neurochem Res.36, 1293-1303, 2011. |
●Tsutsumi K, Takano T, Endo R, Fukuda M, Ohshima T,Tomomura M, Hisanaga S. (2010) Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.
PLoS ONE 5(4): e10260. doi:10.1371/journal.pone.0010260
●Jin J, Suzuki H, Hirai S, Mikoshiba K, Ohshima T. (2010) JNK phosphorylates
Ser332 of doublecortin and regulates its function in neurite extension
and neuronal migration.
Dev. Neurobiol. 70:929-942.
●Ito Y, Tanaka H, Okamoto H, Ohshima T. (2010) Characterization of neural
stem cells and their progeny in the adult zebrafish optic tectum.
Dev. Biol. 342, 26-38.
● Amo R, Aizawa H, Takahoko M, Kobayashi M, Takahashi R, Aoki T, Okamoto H. (2010) Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula.
J. Neurosci. 30(4), 1566-1574. |
●Takahashi S, Ohshima T, Hirasawa M, Pareek TK, Bugge TH, Morozov A, Fujieda
K, Brady RO, Kulkarni AB. (2009) Conditional deletion of neuronal cyclin-dependent
kinase 5 in developing forebrain results in microglial activation and neurodegeneration.
American J. Pathology. 176,320-329.
●Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, Goshima
Y. (2009) Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation
of collapsin response mediator protein 2 at tyrosine 32.
J. Biol. Chem. 284, 27393-401.
●Endo R, Saito T, Asada A, Kawahara H, Ohshima T, Hisanaga S. (2009) Commitment
of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated
degradation of p35 Cyclin-dependent kinase 5 activator.
J. Biol. Chem. 284, 26029-39.
●Nakamura F, Ugajin K, Yamashita N, Okada T, Uchida Y, Taniguchi M, Ohshima T, Goshima Y.
Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.
J. Comp. Neurol. 516, 360-375.
●Ohata S, Kinoshita S, Aoki R, Tanaka H, Wada H, Tsuruoka-Kinoshita S,
Tsuboi T, Watabe S, Okamoto H,
Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain,
Development 136, 1653-1663. |
●Kaminosono S, Saito T, Oyama F, Ohshima T, Asada A, Nagai Y, Nukina N,
Hisanaga S.
Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through
the effect on microtubule stability.
J. Neurosci. 28, 8747-55.
●Nishiwaki Y, Komori A, Sagara H, Suzuki E, Manabe T, Hosoya T, Nojima
Y, Wada H, Tanaka H, Okamoto H, Masai I,
Mutation of cGMP phosphodiesterase 6alpha'-subunit gene causes progressive
degeneration of cone photoreceptors in zebrafish,
Mech. Dev. 125, 932-946. |
●Hirota Y, Ohshima T, Kaneko N, Ikeda M, Iwasato T, Kulkarni AB, Mikoshiba K, Okano H, Sawamoto K.
Cyclin-dependent kinase 5 is required for control of neuroblast migration
in the postnatal subventricular zone.
J. Neurosci. 27, 12829-38.
●Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, Ohshima T, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y.
Regulation of spine development by semaphorin3A through cyclin-dependent
kinase 5 phosphorylation of collapsin response mediator protein 1.
J. Neurosci. 27, 12546-54.
● Remedios R, Huilgol D, Saha B, Hari P, Bhatnagar L, Kowalczyk T, Hevner RF, Suda Y, Aizawa S, Ohshima T, Stoykova A, Tole S.
A stream of cells migrating from the caudal telencephalon reveals a link
between the amygdala and neocortex.
Nat. Neurosci. 10, 1141-50.
●Ohshima T, Hirasawa M, Tabata H, Mutoh T, Adachi T, Suzuki H, Saruta K,
Iwasato T, Itohara S, Hashimoto M, Nakajima K, Ogawa M, Kulkarni AB, Mikoshiba
K.
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal
migration and proper dendrite development of pyramidal neurons in the cerebral
cortex.
Development 134, 2273-2282.
●Ohshima T, Suzuki H, Morimura T, Ogawa M, Mikoshiba K.
Modulation of Reelin signaling by Cyclin-dependent kinase 5. Brain Res.
1140, 84-95.
●Hayashi K, Ohshima T, Hashimoto M, Mikoshiba K.
Pak1 regulates dendritic branching and spine formation.
Dev. Neurobiol. 67, 655-669.
●Tanaka H, Maeda R, Shoji W, Wada H, Masai I, Shiraki T, Kobayashi M, Nakayama R, Okamoto H,
Novel mutations affecting axon guidance in zebrafish and a role for plexin
signaling in the guidance of trigeminal and facial nerve axons.
Development 134, 3259-3269. |
●Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T. Goshima Y.
CRMP1 mediates Reelin signaling in cortical neuronal migration.
J. Neurosci. 26, 13357-62.
●Hayashi K, Pan Y, Shu H, Ohshima T , Kansy W J, White C L III, Tamminga C A, Sobel A, Curmi P A, Mikoshiba K, Bibb J A.
Phosphorylation of the tubulin binding protein, stathmin by Cdk5 and MAP kinase in the brain. J. Neurochem. 99, 237-250.
● Wada H, Tanaka H, Nakayama S, Iwasaki M, Okamoto H,
Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain.
Development 133, 4749-4759. |
●Li C, Sasaki Y, Takei K, Yamamoto H, Shouji M, Sugiyama Y, Kawakami T,
Nakamura F, Yagi T, Ohshima T, Goshima Y.
Correlation between Semaphorin3A-induced facilitation of axonal transport
and local activation of a translation initiation factor eukaryotic translation
initiation factor 4E.
J. Neurosci. 24, 6161-6170.
●Wei F, Nagashima K, Ohshima T. Saheki Y, Matsushita M, Yamada Y, Mikoshiba
K, Seino Y, Matsui H, Tomizawa K.
Cdk5-dependent regulation of glucose-stimulated insulin secretion.
Nat. Med. 11, 1104-1108.
●Ohshima T, Ogura H, Tomizawa K, Hayashi K, Suzuki H, Saito T, Kamei H, Nishi A, Bibb J A, Hisanaga S, Matsui H, Mikoshiba K.
Impairment of hippocampal long-term depression and defective spatial learning
and memory in p35 mice.
J. Neurochem. 94, 917-25.
●Wei F, Tomizawa K, Ohshima T, Asada A, Saito T, Nguyen C, Bibb J A, Ishiguro K, Kulkarni A B, Pant H C, Mikoshiba K, Hisanaga S.
Control of Cdk5 activity by glutamatergic regulation of p35 stability.
J. Neurochem. 93, 502-512.
●Takahashi S, Ohshima T, Cho A, Sreenth T, Iadaroa M J, Pant H C, Kim Y, Narin A C, Brady R O, Greegard P, Kulkarni A B.
Increased activity of cyclin-dependent kinase 5 leads to attenuating of
cocaine-mediated dopamine signaling.
Proc. Natl. Acad. Sci. USA 102, 1737-1742.
●Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y.
Semaphorin-3A signaling is mediated via sequential Cdk5-GSK3b phosphorylation
of CRMP2：implication of common phosphorylating mechanism underlying axon
guidance and Alzheimer’s disease.
Genes to Cells 10, 165-179.
●Wada H, Iwasaki M, Sato T, Masai I, Nishiwaki Y, Tanaka H, Sato A, Nojima Y,Okamoto H, Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryos.
Development 132, 2273-2285.
●Kawakami A, Nojima Y, Toyoda A, Takahoko M, Satoh M, Tanaka H, Wada H,
Masai I, Terasaki H, Sakaki Y, Takeda H, Okamoto H,
The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling.
Curr. Biol. 8, 480-488
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