Official Title

Assistant Professor
Research Institute for Science and Engineering

Research Fields

Vascular biology, extracellular matrix, thoracic aortic aneurysm, molecular biology, physical chemistry, photochemistry, spectroscopy, molecular imaging, Raman spectroscopy

Research

Thoracic aortic aneurysms (TAAs) are life-threatening diseases that have the risk of aortic rupture and dissection. Extracellular matrix (ECM) is the main component in the vessel, such as elastic fibers and collagen. Temporal changes of the ECM including aortic remodeling are caused aTAA, but still not clear the mechanism of aTAA with the aortic remodeling. Raman spectroscopy is non-invasive light technique to provide the difference in the molecular level
Recently, Raman measurements are applied to the biomedical field to elucidate disease features. For my research, I utilized the mouse model and Raman microspectroscopy with multivariate data analysis to elucidate the disease-related Raman signals, indicating the alteration of amino acids in the aneurysm lesion. Furthermore, a combination of Raman measurements and artificial intelligence to identify molecular tissue patterns specific to pre-ruptured signals will have the potential for the novel diagnostic markers.

Selected publications

1. Sugiyama K, Marzi J, Brauchle EM, Ando M, Yamashiro Y, Remkhelawon B, Schenke-Layland K, Yanagisawa H., “Raman Microspecctroscopy and Imaging Reveal Novel Biomarkers Specific for Thoracic Aortic Aneurysms”, Sneak Peek, Cell Press, CR-MEDICINE-D-20-00137, 2020

2. Sugiyama K, Horigome H, Lin L, Murakami T, Yamashiro Y, Matsuura H, Yoda H, Yanagisawa H., “Novel ELN mutation in a Japanese family with a serve form of supravalvular aortic stenosis.”, Mol. Genet. Genomic. Med., Wiley Online Library, 7(11):e986, 2019.

3. Yamashiro Y, Thang BQ, Shin SJ, Lino CA, Nakamura T, Tim J, Sugiyama K, Tokunaga C, Sakamoto H, Osaka M, Davis EC, Wagenseil JE, Hiramatsu Y, Yanagisawa H., “Role of Thrombospondin-1 in mechanotransduction and development of thoracic aortic aneurysm in mouse and humans”, Circ. Res., AHA, 123(6):660-672, 2018.

4. Okutsu T, Taguchi T, Korenaga J, Kuroiwa T, Ishikawa Y, Ishizuka S, Sugiyama K, Horiuchi H, Hiratsuka H., “Investiation of the mechanism of photochemically-induced lysozyme crystallization”, J. Photochem. Photobiol. A., ELSEVIER, 321, 180-186, 2016. Pharmacol.132:133-142. (2017)