Official Title

Professor
Department of Life Science and Medical Bioscience
School of Advanced Science and Engineering, Waseda University

Research Fields

molecular-oncology

Research

Many genes are thought to be involved in human cancer. Discovery and functional analysis of cancer-associated genes is necessary to understand how cancer cells continuously grow and metastasize. Purpose of our research is to discover novel oncogenes using genomics and proteomics techniques and to analyze their functions towards the development of efficacious targeted therapeutics．

Selected Publications

1. Nakayama, J., Ito, E., Fujimoto, J., Watanabe, S. & Semba, K.
Comparative analysis of gene regulatory networks of highly metastatic breast cancer cells established by orthotopic transplantation and intra-circulation injection
2017 Feb 1 In : International Journal of Oncology. 50, 2, p. 497-504 8 p.

2. Li, T., Amari, T., Semba, K., Yamamoto, T. & Takeoka, S.
Construction and evaluation of pH-sensitive immunoliposomes for enhanced delivery of anticancer drug to ErbB2 over-expressing breast cancer cells
2017 Apr 1 In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 3, p. 1219-1227 9 p.

3. Hoshi, H., Hiyama, G., Ishikawa, K., Inageda, K., Fujimoto, J., Wakamatsu, A., Togashi, T., Kawamura, Y., Takahashi, N., Higa, A., Goshima, N., Semba, K., Watanabe, S. & Takagi, M.
Construction of a novel cell-based assay for the evaluation of anti-EGFR drug efficacy against EGFR mutation
2017 Jan 1 In : Oncology Reports. 37, 1, p. 66-76 11 p.

4. Yamamoto, M., Sakane, K., Tominaga, K., Gotoh, N., Niwa, T., Kikuchi, Y., Tada, K., Goshima, N., Semba, K. & Inoue, J. I.
Intratumoral bidirectional transitions between epithelial and mesenchymal cells in triple-negative breast cancer
2017 Jun 1 In : Cancer Science. 108, 6, p. 1210-1222 13 p.

5. Okita, Y., Kimura, M., Xie, R., Chen, C., Shen, L. T. W., Kojima, Y., Suzuki, H., Muratani, M., Saitoh, M., Semba, K., Heldin, C. H. & Kato, M.
The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB
2017 Apr 11 In : Science Signaling. 10, 474