Official Title

Professor
Department of Life Science and Medical Bioscience
School of Advanced Science and Engineering, Waseda University

Examples of Classes Taught

Current Topics in Biosciences

Research Fields

cerebellar Purkinje cell,cerebellar slice,synaptic plusticity

Research

My target is to understand how the higher functions of the central nervous system are organized by the molecular mechanisms and intracellular signaling pathways in neurons using electrophysiology combined with imaging techniques as well as molecular biological methods on brain slice preparations and cultured neurons. I focus on the molecular basis of synaptic plasticity by quantitative measurements of spatio-temporal dynamics of intracellular signaling pathways confined in compartments of neural dendrites.

Selected publications

1. Bozong Xu, Ayumi Kumazawa, Shunsuke Kobayashi, Shin-ichi Hisanaga, Takafumi Inoue, Toshio Ohshima.
Cdk5 activity is required for Purkinje cell dendritic growth in cell-autonomous and non-cell-autonomous manners
Developmental Neurobiology, 77:1175-1187 (2017), doi:10.1002/dneu.22507

2. Yoshikazu Nakamura, Kaori Kanemaru, Kengo Totoki, Takatsugu Fukuyama, Madoka Shoji, Hisae Kaneko, Kanako Shiratori, Atsuko Yoneda, Takafumi Inoue, Yoichiro Iwakura, Kenji Kabashima, Kiyoko Fukami.
Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity
Cell Death and Differentiation, 24:1079-1090 (2017), doi:10.1038/cdd.2017.56

3. Masaru Ishibashi, Iryna Gumenchuk, Kenichi Miyazaki, Takafumi Inoue, William N. Ross, Christopher S. Leonard.
Hypocretin/orexin peptides alter spike-encoding by serotonergic dorsal raphe neurons through two distinct mechanisms that increase the late afterhyperpolarization
Journal of Neuroscience, 36:10097-10115 (2016), doi:10.1523/JNEUROSCI.0635-16.2016, pmid:27683906,

4. Haruki Odaka, Tadahiro Numakawa, Aya Yoshimura, Shingo Nakajima, Naoki Adachi, Yoshiko Ooshima, Takafumi Inoue, Hiroshi Kunugi.
Chronic glucocorticoid exposure suppressed the differentiation and survival of embryonic neural stem cells: possible involvement of ERK and PI3K/Akt signaling in the neuronal differentiation
Neuroscience Research, 113:28-36 (2016), doi:10.1016/j.neures.2016.07.002, pmid:27432545

5. Junya Toba, Miyu Nikkuni, Masato Ishizeki, Aya Yoshii, Naoto Watamura, Takafumi Inoue, Toshio Ohshima.
PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice
Biochemical and Biophysical Research Communications, 473:1039-1044 (2016), doi:10.1016/j.bbrc.2016.04.012, pmid:27059136

Links

http://webdav.biomed.sci.waseda.ac.jp/inouelab-web/member-e.html