Nobuhito Goda
Official Title
Professor
Department of Life Science and Medical Bioscience
School of Advanced Science and Engineering, Waseda University
Research Fields
Pathological medical chemistry、Environmental physiology (including physical medicine and nutritional physiology)
Research
High calorie intakes and low physical activity cause metabolic diseases such as obesity, diabetes, and fatty liver, which are tightly associated with and considered as risk factors for cancer, cardiac infarction, and stroke. Numbers of patients suffering from the metabolic diseases are rapidly increasing in Japan and worldwide, but effective pharmacological interventions are limited. In our research, we focus on “hypoxia”, a common hallmark of metabolic diseases and try to elucidate the importance of hypoxic response in the development and progression of the diseases using gene-modified animals such as mice and drosophila. Our final goal is to establish new therapeutic against the metabolic diseases by investigating molecular mechanisms in detail.
Selected Publications
1. Shinjo, S., Jiang, S., Nameta, M., Suzuki, T., Kanai, M., Nomura, Y.
& Goda, N.
Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid–induced insulin resistance
Experimental Cell Research. 359, 1, p. 86-93 8 p.
2. Arai, T., Ono, Y., Arimura, Y., Sayama, K., Suzuki, T., Shinjo, S.,
Kanai, M., Abe, S. I., Semba, K. & Goda, N.
Type i neuregulin1α is a novel local mediator to suppress hepatic gluconeogenesis in mice
2017 Feb 20 In : Scientific Reports. 7, 42959
3. Shimura, D., Kusakari, Y., Sasano, T., Nakashima, Y., Nakai, G., Jiao,
Q., Jin, M., Yokota, T., Ishikawa, Y., Nakano, A., Goda, N. & Minamisawa,
S.
Heterozygous deletion of sarcolipin maintains normal cardiac function
2016 Jan 1 In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 1, p. H92-H103
4. Takikawa, A. , Mahmood, A. , Nawaz, A. , Kado, T. , Okabe, K. , Yamamoto,
S. , Aminuddin, A. , Senda, S. , Tsuneyama, K. , Ikutani, M. , Watanabe,
Y. , Igarashi, Y. , Nagai, Y. , Takatsu, K. , Koizumi, K. , Imura, J. ,
Goda, N. , Sasahara, M. , Matsumoto, M. , Saeki, K. & 4 others
HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance
2016 Dec 1 In : Diabetes. 65, 12, p. 3649-3659 11 p.
5. Semba, H. , Takeda, N. , Isagawa, T. , Sugiura, Y. , Honda, K. , Wake,
M. , Miyazawa, H. , Yamaguchi, Y. , Miura, M. , Jenkins, D. M. R. , Choi,
H. , Kim, J. W. , Asagiri, M. , Cowburn, A. S. , Abe, H. , Soma, K. , Koyama,
K. , Katoh, M. , Sayama, K. , Goda, N. & 4 others
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
2016 May 18 In : Nature Communications. 7, 11635