Masahira Hattori

Official Title

Cooperative Major of Advavnced Health Science
Graduate School Collaborative Education Curriculum, Waseda University

Research Fields

Genomics & Metagenomics, Bioinformatics


 Human body sites are colonized by over 100 trillion cells of microbes which form the microbiome having profound influences on host physiological states. Our research focus is elucidation of the overall structure of microbiome and its physiological functions via interactions with host cells. For this, we are also developing culture-independent approaches such as metagenomics, bioinformatics and statistics based on next-generation sequencing (NGS).

Selected Publications

1. Chiou TY, Suda W, Oshima K, Hattori M, Matsuzaki C, Yamamoto K, Takahashi T.
Lactobacillus kosoi sp. nov., a fructophilic species isolated from koso, a Japanese sugar-vegetable fermented beverage.
Antonie Van Leeuwenhoek (2018) in press. doi:10.1007/s10482-018-1019-7.

2. Koizumi T, Hattori M, Nara K.
Ectomycorrhizal fungal communities in alpine relict forests of Pinus pumila on Mt. Norikura, Japan.
Mycorrhiza (2018) in press. doi:10.1007/s00572-017-0817-5.

3.Costea PI, Hildebrand F, Manimozhiyan A, Backhed F, Blaser MJ, Bushman FD, de Vos WM, Ehrlich SD, Fraser CM, Hattori M, Huttenhower C, Jeffery IB, Knights D, Lewis JD, Ley RE, Ochman H, O'Toole PW, Quince C, Relman DA, Shanahan F, Sunagawa S, Wang J, Weinstock GM, Wu GD, Zeller G, Zhao L, Raes J, Knight R, Bork P.
Enterotypes in the landscape of gut microbial community composition.
Nat. Microbiol. (2018) 3:8-16. doi:10.1038/s41564-017-0072-8.

4. Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T; INDIGO Study Group.
Efficacy of Indigo naturalis in a Multicenter Randomized Controlled Trial of Patients with Ulcerative Colitis.
Gastroenterology (2017) in press. doi:10.1053/j.gastro.2017.11.024.

5. Otsubo T, Yamada K, Hagiwara T, Oshima K, Iida K, Nishikata K, Toyoda T, Igari T, Nohara K, Yamashita S, Hattori M, Dohi T, Kawamura YI.
DNA hypermethyation and silencing of PITX1 correlated with advanced stage and poor postoperative prognosis of esophageal squamous cell carcinoma.
Oncotarget. (2017) 8:84434-84448. doi:10.18632/oncotarget.21375.

Links (Link to The University of Tokyo)